Title: Effects of levodopa on the cerebral dopamine transporter in healthy aged SD rats
Abstract: Objective To observe the effects of chronic levodopa administration on cerebral dopamine transporter in healthy aged SD rats.Methods Twelve healthy aged SD rats was divided into three groups,which was respectively gavaged with high-dose of levodopa (150 mg/kg), low-dose of levodopa (50mg/kg) and NS everyday for four months. After levodopa was stopped for twenty-four hours, 0.2 ml of 99mTc-TRODAT-1 (800 μGi) was injected into the rats through vena caudalis. Three hours later, the rats were sacrificed and the wet weight of striatum, cerebral cortex, cerebella and brain stem was weighed. We measured the counts of radiation and calculated the numerical value of ID.Results The activity of ID in striatum was ( 0.764± 0.129) in high-dose group and ( 0.928± 0.145) in low-dose group. Compared with the control group ( 1.562± 0.289), the differences were significant ( P0.001, P0.05). There was no difference in other brain segments.Conclusion Chronic levodopa administration can induce down-regulated dopamine transporter in the striatum.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot