Title: Expression of HER-2,MT1-MMP and CD147 in gastric carcinoma and their significances
Abstract: Purpose To investigate the expression of HER-2,MT1-MMP and CD147 in gastric carcinoma and to find out their correlations with the biologic behaviors of the tumor.Methods HER-2,MT1-MMP and CD147 proteins were detected by immunohistochemical staining in 10 cases of normal gastric tissue and 178 cases of gastric carcinoma.Results All of the expression level of HER-2,MT1-MMP and CD147 protein in gastric carcinoma tissues was significantly higher than that in normal gastric tissues(P0.05).The expression of them in the subgroup of poorly-differentiated with serosal invasion and lymph nodes metastasis was significantly higher than the other subgroup of well-differentiated without serosal invasion and lymph nodes metastasis(P0.01).And the expression of HER-2 protein in the esophagogastric junction was higher than in the stomach.There was a positive correlation trend between the expression of HER-2 and MT1-MMP protein in gastric carcinoma,but without significant difference,with Pearson coefficient of 0.301(P=0.05).The positive correlation was found between CD147 and MT1-MMP protein in gastric carcinoma,with Pearson coefficient 0.887(P0.01).Conclusions Over-expression of HER-2,MT1-MMP and CD147 is detected in gastric carcinoma,with close relationships of HER-2 and CD147 with MT1-MMP,which suggests that all the three proteins may be involved in the invasiveness and metastasis of gastric carcinoma.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 2
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