Title: Expression of BAG-1 in Laryngeal Squamous Cell Carcinoma and Its Relationship with p53 Gene and Cell Apoptosis
Abstract: Objective Recent studies have shown that BAG-1 expression is frequently altered in many malignant cells. This study aimed to investigate the clinical significance of BAG-1 expression and its relationship with p53 gene and cell apoptosis in laryngeal squamous cell carcinoma (LSCC), and to further explore the relationship between the BAG-1 and the occurrence, development, prognosis in LSCC. Methods Using the method of immunohistochemical SP staining method examined the expression of BAG-1, p53 protein in 68 cases of LSCC and 30 cases of para-tumour tissues. Using the method of TUNEL technique detected apoptosis index (AI) of tumor cells. The grayscale of positive signals were quantified by image processing computer. Results The percentage of positive expression of BAG-1 in LSCC and para-cancerous were 76.5% , 16.7% , respectively, and the expression of BAG-1 was significantly higher than that in para-cancerous tissues (P 0.05 ); and that in 5-year survival patients was lower than that of the latter (P 0.05 ); and BAG-1 in LSCC with nucleus staining had worse prognosis than that with cytoplasm staining (P 0.05 );the expression of BAG-1 significantly correlated with apoptosis (r= -0.602 , P 0.01 ), but not with p53 expression. The average AI of patients with positive expression of BAG-1 was lower than that of patients with negative expression of BAG-1 (P 0.05 ). Conclusion Overexpression of BAG-1 may play an important role in the development and apoptosis of LSCC. It is feasible for early diagnosis and prognosis.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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