Title: Effects of Yangxue Qingnao Granule on Hemorrheology and Endotheline in Patients with Acute Cerebral Infarction
Abstract: OBJECTIVE:To evaluate the curative efficacy of Yangxue qingnao granule and its effects on the hemorrheology and endotheline(ET-1)in patients with acute cerebral infarction(ACI).METHODS:A total of 255 patients with ACI were divided into two groups:120 in the control group received routine therapy (mannitol,citicoline,troxerutin,piracetam,and aspirin),and the other 135(trial group) received the above-mentioned routine therapy in combination with Yangxue qing-nao granule(4 g/pouch,one pouch/time,t.i.d) for 8 weeks. The clinical efficacy in two groups were observed with the scores of nervous system defect as outcome measures,meanwhile,the changes of hemorrheology and ET-1 after treatment were observed as well. RESULTS:There were no significant differences between the trial group and the control group in total effective rate(88% vs. 93%),but significant differences were noted in total remarkable-efficacy rate (64% vs. 30%,P0.01). The changes in blood platelets count for both groups were nonsignificant before and after treatment. Blood coagulation factor-Ⅰ levels in both groups were markedly decreased at 4 and 8 weeks,but no significant differences were noted between the two groups. At 8 weeks,the haematocrit,blood viscosity and plasma viscosity in both groups improved significantly and there were no significant differences between the two groups. Plasma ET-1 in the trial group decreased significantly after treatment (P0.01) and the differences between the two groups were significant(P0.01).CONCLUSION:The higher total remarkable-efficacy rate noted in the trial group is associated with the action of Yangxue qingnao granules in down-regulating haematocrit and blood viscosity,and its regulatory effect on vasoactive substance may play a key role.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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