Title: A matched control research of defibrase in treating acute cerebral infarction
Abstract: AIM To observe the clinical effectiveness andsafety of defibrase in treating acute cerebral infarction. METHODS 64 patients with acute cerebral infarction were randomly divided into 2 groups: treatment group using defibrase 10 U initially, 5 U at 2-8 days and 10, 12, 14 d; and control group. The efficacy was evaluated before and 14 days after the treatment according to the score of clinical neural function impairment. The data was analyzed statistically by χ 2 test. RESULTS Firstly, in the treatment group 8 cases were cured (25.0%), 15 markedly improved (46.9%) while in the control group 4 cases were cured (12.5%), 8 markedly improved (25.0%). Both total effectiveness and obvious effectiveness between the two groups (90.6%), (71.9%) in treatment group, (68.8%), (37.5%) in control one, respectively) were all statistically significant ( P 0.01). Secondly there was a significant difference between obvious effectiveness 12 h within (91.7%) and 12 h post accidence (55.0%) in the treatment group. Lastly, in the treatment group a statistically significant difference also exists between thrombosis index, platelet agglutination rate, blood viscosity and fibrinogen level pre and post treatment ( P 0.01), except hematocrit ( P 0.05). CONCLUSION There was significant effectiveness when defibrase was applied early in treating acute cerebral infarction. Defibrase is significantly effective in treating acute cerebral infarction.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot