Title: Expression and clinical significance of IL-17 and MMP-9 in NSCLC
Abstract: Objective To investigate the expression of IL-17 and MMP-9 in non-small cell cancer in NSCLC patients,to analyze the differentiation of expression,and the relationship between them and the clinical significance.Methods The expression of IL-17 and MMP-9 were detected in 60 NSLCL samples and lung tissues as control by PV9000 immunohistochemical technique.Results The positive expression of IL-17 and MMP-9 was detected in 60 cases NSCLC was 78.3% and 80.0% respectively which was significantly higher than in adjacent non-tumor tissues(P0.05).The positive expression of IL-17 and MMP-9 were not correlated to age,sex,pathologic types and differentiation.The survival rate was different between NSCLC tissues with positive and negative IL-17 and MMP-9 expression(P0.05).Conclusion IL-17 and MMP-9 may play important roles in NSCLC invasion and metastasis.Over expression of IL-17 and MMP-9 could act as a reference to evaluate unfavorable prognosis of NSCLC.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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