Title: Transbronchial Arterial Chemoembolization with Carbodoxin-Lipiodol Mixture for the Treatment of Lung Cancer
Abstract: Objective To evaluate transbronchial arterial chemoembolization with carbodoxin Lipiodol mixture in the treatment of lung cancer. Materials and Methods In this study 50 patients with lung cancer were collected, of which adenocarcinoma was seen in 17, squamous cell carcinoma in 30 and small cell carcinoma in 3. The clinical staging was 4 cases in Ⅱa, 17 in Ⅱb, 22 in Ⅲa and 7 in Ⅲb. Bronchial arteriography was carried out to identify the tumor feeding branch for super selective catheterization with coaxial microcatheter technique. After 200mg carboplatin, 10~20mg mitomycin C and 500~1000mg 5 FU was infused, embolization with the mixture of 3~10ml Lipiodol and 100mg carboplatin was performed.Results (1) Embolized arteries included left bronchial artery (n=5) and its tumor branch (n=13), right bronchial artery (n=4) and its tumor branch (n=21), left branch (n=3) and right branch (n=4) in cases with common bronchial artery. (2) Short term effectiveness: complete response (CR) was achieved in one cases, while partial response (PR) in 37, steady disease (SD) in 12, and no deterioration was seen. The total effectiveness (CR plus PR) was up to 76%. Clinical symptoms were relieved in 44.4%. (3) Complications: Transient myelitis developed in 1 of 9 cases in whom embolization of bronchial artery trunk was done. Intercostal artery ischemic symptoms occurred in all 3 patients who had a common trunk of bronchial intercostal arteries and who had the bronchial artery embolized. None of the above complications developed in the patients in whom the tumor feeding branch from the bronchial artery was embolized. During the procedure, Lipiodol deposit in pulmonary arterial branches was seen in 12% of cases, and slight respiratory distress developed in 4%, which was relieved after symptomatic management.Conclusion Transbronchial arterial chemoembolization with carbodoxin Lipiodol mixture has good short term effect in the treatment of lung cancer. Super selective tumor feeding artery catheterization may avoid potential ischemic complications.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot