Title: Clinical value of serum Cystatin C for detection of renal function in patient after liver resection
Abstract: Objective To investigate the clinical value of serum Cystatin C(Cys C) for monitoring of renal function in patient after liver resection.Methods 24-hours creatinine clearance(CCr),serum level of Cys C and serum creatinine(SCr) were measured in 141 patients after liver resection.x2 test,Pearson correlation test and ROC curve were utilized to evaluate the diagnostic significance of Cys C.Results Thirty-two out of 141 patients suffered the renal injury.Among these 32 patients,level of Cys C increased in 28 cases,whereas the elevation of SCr level in 15 cases were turn out.Cys C and SCr both significantly inversely correlated with CCr(CysC: r=-0.742,P0.001;SCr: r=-0.503,P0.001).However,coefficient of Cyst C to CCr was obviously higher than that of SCr.Moreover,using ROC curve,Cystatin C was diagnostically superior to SCr(area under the curve for cystatin C 0.815,AUC for creatinine 0.643).Conclusion Cys C is a more accurate marker of renal injury in patients after liver resection.Detection of Cys C level in these patients can contribute the prevention of renal injury or hepatorenal syndrome.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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