Title: Effects of thalidomide on tumor growth and invasion of human hepatocellular carcinoma in nude mice
Abstract: Objective To evaluate the effects of thalidomide on the tumor growth and metastasis of human hepatocellular carcinoma in nude mice.Methods The models of nude mice bearing human hepatocellular carcinoma with high potential of metastasis were established and randomly divided into 4 groups.Thalidomide (200 mg/kg),paclitaxel (13 mg/kg),or Thalidomide (200 mg/kg) plus paclitaxel (13 mg/kg),which were dissolved in 0.5% CMC suspension,was peritoneally injected respectively for each group from the second day of building model.The mice with 0.5% CMC alone served as control group.The mice were sacrificed on the 30th day. Tumor size and weight and metastases in lungs were measured.The levels of CD34 and VEGF mRNA in tumor tissue was detected by immunohistochemical and semi-quantitative techniques reapectively,and microvessel density (MVD) was counted.Results No statistical difference was found in tumor growth between thalidomide group and control group.MVD,VEGF mRNA and loci of metastases in lung tissues in each treatment group were less than in control group (P 0.05), especially in the combined treatment group.Conclusion Thalidomide can significantly inhibit angiogenesis and metastasis of hepatocellular carcinoma despite its poor tumor growth inhibitory effect.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot