Title: THE EFFECTS OF BETA-CAROT ENE FROM DUNALIELIA SALINA ON EXPERIMENTAL ATHEROSCLEROSIS IN QUAILS
Abstract: Objective To study the effects of beta car otene from dunalielia salina on experimental atherosclerosis in quails and its p ossible mechanisms. Methods In this study, 120 healthy male quails were divided rando mly into six groups based on oral feeding with different diet everyday. Eight we eks later, all high cholesterol diet for quails was changed to ordinary one dur ing the last two weeks(from nine to 11 weeks) . At the end of seventh and 10th w eeks, the venous blood of quails in each group was collected for detection of se rum total cholesterol (TC), triglyceride (TG), high density lipoprotein choleste rol(HDL C), low density lipoprotein cholesterol(LDL C) and the value of LDL C , VLDL C and the ratio of HDL C/TC were calculated. Ten quails in each group were killed and the aorta artery taken out, the contents of total cholesterol(T C), free cholesterol(FC) and cholesterol ester (CE) in arterial wall measured. Results At the end of eighth week, the levels of TC and CE in the arterial wall of groups B and C were lower than those of higher cholesterol d iet control group ( F=5.36,15.89; q=3.94-5.38; P 0.05). At the end of 11th week, the levels of serum TC, LDL C and VLDL as well as TC and CE in arterial wall of groups B, C, and D were lower and the rate of HDL C/TC was higher than those of high cholesterol diet controls ( F=5.67-37.27,q=2.17-5.13,P 0 .05 ). Conclusion LDL C could regulate lipid metabolism, scavenge the l ipoperoxidation and inhibit the deposition of cholesterol and its ester in the arterial wall to prevent the development of AS.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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