Title: Intervention of Xuebijing injection(血必净注射液) against early hypercoagulability in patients with severe sepsis
Abstract: Objective To approach the mechanism and intervention of Xuebijing injection(血必净注射液) against the hypercoagulability state in patients with severe sepsis.Methods Forty-two patients admitted into the emergency intensive care unit(EICU) with severe sepsis were randomly divided into traditional Chinese medicine(TCM) group(22 cases) and routine group(20 cases).The people who came at the same period for physical examination or the healthy volunteers were taken as the normal control group(15 cases).The routine group was treated according to the guide for severe sepsis.Beside the treatment used in the routine group,in the TCM group,2 times of 50 ml Xuebijing dripping venous injection everyday for consecutive 7 days were added.The venous blood was collected in the morning to determine the thrombus precursor protein(TpP),thrombomodulin(TM),von wilebrand factor(vWF) and granular membrane protein 140(CD62P) respectively by enzyme linked immunosorbent assay(ELISA) and flow cytometry in the physical examination day of contrast or healthy control group,and on the 1st,3rd,5th, 7th day after admission of the TCM group and routine group.The death rate within 28 days was recorded.Results From the 1st day the results of CD62P,TpP,TM,and vWF in the two treatment groups were significantly higher than those in the normal control group(all P0.01).With the prolongation of time,all index values of the two treatment groups presented a downward trend and there were statistical significances between the 1st and 7th day(P0.05 or P0.01).All index values at the same time points in the TCM group were lower than those in the routine group(P0.05 or P0.01).The expressions of CD62P,TpP,TM in TCM group showed no statistical significance with those of the normal control group on the 7th day(all P0.05).The death rate in the routine group within 28 days was 40.0%(8/20),and 36.0%(8/22) in the TCM group,which showed no statistical meaning (P0.05).Conclusion Hypercoagulability state can occur in the early stage of severe sepsis.Xuebijing injection can effectively intervene on the hypercoagulability state in the early stage of severe sepsis.The mechanism is probably related to the protection of endothelium from injury.But it has no influence on the death rate.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot