Title: Changes of CT Perfusion Imaging of Rabbit Bearing VX2 Hepatoma After Interventional Treatment
Abstract: Objective: To explore the value of CT perfusion imaging(CTPI) in evaluating the effect of interventional treatment in rabbit VX2 hepatoma.Methods: Twenty-five hepatoma models of New Zealand rabbits were established by implanting VX2 tumor fragments into liver.CTPI was adopted before treatment,and on the 1st and 3rd day after interventional treatment by Seldinger technique.Perfusion data were analyzed by GEAW4.2 perfusion software,the perfusion pictures and parameters of hepatic blood flow(HBF),hepatic blood volume(HBV),mean transit time(MTT),permeability surface area product(PS),and hepatic arterial fraction(HAF) were acquired,and the results were compared with pathological outcomes after the rabbits were executed.Results: The space-occupying lesions were showed in all 25 rabbits' liver on CT plain scans,and 20 rabbits were successfully underwent interventional treatment.HBF,HBV,PS,HAF,and MTT were different between the tumor margin area and the adjacent normal liver tissues(all P0.05).And these indices of margin area changed significantly after interventional treatment(all P0.05).Pathological results showed that necrosis regions increased after interventional treatment.Conclusion: CTPI can effectively evaluate the effect of interventional treatment in rabbit VX2 hepatoma.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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