Title: Study on lead,superoxide dismutase and malondialdehyde contents in serum and seminal plasma of patients with male infertility
Abstract: Objective: To reveal the causes of superoxide dismutase(SOD) activity decrease and malondialdehyde(MDA) content increase of patients with male infertility by measuring the lead level,SOD activity and MDA content in serum and seminal plasma of those without obvious lead pollution exposure history.Methods: 95 male infertile patients with abnormal semen routine examination results were randomly selected as the infertile group while 100 people with normal semen routine examination results were selected as the control group.The SOD activity was determined using the xanthine oxidase colorimetric method,the MDA content was determined using thiobarbituric acid colorimetric method,and the lead content was determined using atomic absorption spectrometry.Results: The serum SOD activity of the male infertile group was not significantly different compared with that of the control group.The MDA content was significantly different compared with that of the control group(P0.01).The lead content was significantly different compared with that of the control group(P 0.05).The semen SOD activity of the male infertile group was significantly lower than that of the control group(P0.01).The MDA and lead contents were significantly higher than those of the control group(P0.01).Conclusion: The lead content increase in the serum and seminal plasma maybe the main cause of semen SOD activity decrease and MDA content increase.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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