Title: The Developmental Observe of Th1/Th2-type Cytokines in Peripheral Blood in Patients with Chronic Hepatitis B
Abstract: Objective To study the changes and clinical significance of Th1/Th2-type cytokines in patients with chronic hepatitis(CH)B.Methods Blood samples were collected from 34 patients with chronic hepatitis B when the patients were admitted to hospital,another blood samples the liver function of these patients was normal.Serum levels of Th1 cytokines(IL-2,IFN-γ) and Th2 cytokines(IL-4,IL-10) were measured by double-antibody sandwich ELISA.Results Compared with the normal control,IL-2 decreased significantly,and CH-ⅠCH-ⅡCH Ⅲ;IL-10 increased significantly in CH-Ⅱ and CH-Ⅲ,and CH-ⅢCH-ⅡCH-Ⅰ.After the treatment,serum levels of IL-10 and HBV DNA deceased significantly in CH-Ⅱ and CH-Ⅲ.Serum levels of IL-2,IFN-γ and IL-4,IL-10 were no related to the HBV quantity.Conclusion There is cellular immune disorder in chronic hepatitis B.The function of Th2 cell increases when the patients are admitted to hospital.The function of Th2 cell is more powerful when the condition of patients is severer.When the liver function is normal,the function of Th2 cell and the HBV quantity decrease.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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