Title: The Treatment Research on Childhood Refractory Nephrotic Syndrome and Hyperlipidemia
Abstract: Objective: To study the characteristics of lipid metabolism in childhood refractory nephrotic syndrome and the treatment effects of captopril and Astragalus to childhood refractory nephrotic syndrome and hyperlipidemia. Methods: Forty-two healty children were enrolled as the control and sixty cases of childhood refractory nephrotic syndrome were randomly divided into three groups:the conventional group(group A), the captopril-treated group(group B) and the captopril and Astragalus combination treatment group(group C) and twenty patients were assigned to each group. Blood-lipid figures were determined before treatment and eight, twelve weeks after the treatment to evaluate the effect. Results: (1)The levels of serum TC,TG,LDL-C,HDL-C, apoAI, apoB100 in all sixty patients with refractory nephrotic syndrome increased remarkably compared with the control group (P 0.01).(2)The levels of serum TC,TG,LDL-C decreased (P 0.01) at the end of eight and twelve weeks after the treatment in group B and group C compared with those before treatment.The figure difference was not statistically significant in group A compared with pretreatment(P 0.05). The figures had decrease at the end of twelve weeks after the treatment compared with those at the end of eight weeks only in group C (P 0.05). Conclusion:(1)Obviouse abnormality of lipid is seen in childhood refractory nephrotic syndrome. (2)Combination of captopril and astragalus treatment can reduce severe hyperlipidemia so that prevent the seconday renal injury in these children.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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