Title: Study on the Preparation of D-Histidine by Asymmetric Transformation
Abstract: D-His·(R)-TA salt was obtained by reaction of L-His with (R)-TA in acetic acid in the presence of salicylaldehyde as catalyst.The influences of time,temperature,solvents and catalyst dosage on the reaction were investigated.The optimum reaction conditions are as follows: L-His:(R)-TA: salicylaldehyde=1∶1∶0.1(mol);reaction temperature,90℃; and reaction time,3 h.Treatmet of the obtained D-His·(R)-TA salt with methanol solution of triethylamine gave D-His with 98.7% optical purity and 94.2% yield based on the starting L-His.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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