Title: Clinical effect of specific immunotherapy on patients with chronic urticaria and their serum interleukin-18
Abstract: Objective To explore the clinical effect of specific immunotherapy on patients with chronic urticaria and their serum interleukin-18.Methods 68 patients with chronic urticaria from September 2008 to October 2010 in our hospital were selected as the subjects in this study and were randomly allocated into two groups,including observation group and control group,each of which had 34 cases.In control group,the patients were given antihistamine drug following oral administration with the dosage of 10 mg once a day for three month.In observation group,the patients were given allergen test with fast insertion on skin and specific immunotherapy for 12 months was performed to test specific IgE based on the treatment of control group.The patients in two groups received BCG Polysaccharide and Nucleic Acid preparation following intramuscular with the dosage of 0.5 mg once every other day for 3 months.Results The total effective rates were 82.35% in observation group and 58.82% in control group respectively with statistical significance(P 0.05).For the level of IL-18,there was statistical significance between pretreatment and posttreatment(P 0.01).Besides,there was significant difference between control group and observation group(P 0.01).Conclusion The specific immunotherapy can make IL-18 down regulation and rectify Th1/Th2 cytokine dysfunction in patients with chronic urticaria.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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