Title: Different expression of melatonin and melatonin receptor in human thyroid neoplasm
Abstract: Objective:To investigate the different expression of melatonin and melatonin receptor in patients with thyroid neoplasm.Methods:Thyroid neoplasms(adenocarcinoma and adenoma) and normal thyroid tissue(1cm away from adenoma)and the serum were tested the concentration of melatonin by ELISA. The thyroid neoplasm tissues and normal thyroid tissues were detected the melatonin receptor subtypes with immunohistochemistry and RT-PCR. Results:Thyroid neoplasm homogenate had a higher concentration of MLT than their serum. The group adenocarcinoma was higher than group adenoma and group of normal thyroid tissue, the group adenoma was higher than the group of normal thyroid tissue, but without significance in.Strong MT2 receptor subtype expression that had brown granules deposited in the membrane, cytosol and nuclear of the thyroid cell was observed in group adenocarcinoma than group adenoma and normal thyroid.Weak mt1 receptor subtype expression was observed in all groups. mt1 and MT2 melatonin receptor subtype positive strap expressed in all groups. MT2 in adenocarcinoma had a higher quantity than normal thyroid tissue. The expression of mt1 in adenocarcinoma and mt1, MT2 subtype in adenoma had no significance than normal thyroid tissue.Conclusion:There exists mt1 and MT2 subtype in human thyroid neoplasm tissue, MT2 subtype has association with the occurrence of human adenocarcinoma.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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