Title: Clinical significance of multiple detection indexes for diagnosing systemic lupus erythematosus
Abstract: Objective To investigate the value of polypeptide antibodies spectrum of extractable nuclear antigens(ENA),anti double-stranded DNA(anti-dsDNA) antibodies,immunoglobulin and complement in the diagnosis of systemic lupus erythematosus(SLE).Methods Autoantibodies immunoglobulin and complement in 84 patients with SLE and 90 healthy people were detected;autoantibodies immunoglobulin and complement in 45 patients with SLE treated four months were detected.Results In 84 patients with SLE,the positive rates of anti-dsDNA,anti-Sm-D1,anti Ro/SS-A60,anti-Ro/SS-A52,anti-SSB,anti-U1-SnRNP,anti-Histon,anti-Po and anti-Nucle test were 73.8%,84.8%,83.3%,61.9%,45.2%,42.9%,33.3%,30.9% and 9.5% respectively.Immunoglobulin in the SLE group was significantly higher than that of the control group,complement C3,C4 were significantly lower than those of the control group,showing statistical difference(P0.05).The positive rates of serum anti-dsDNA,anti-Sm-D1,anti Ro/SS-A60,anti-Ro/SS-A52,anti-SSB,anti-U1-SnRNP,anti-Histon,anti-Po and anti-Nucle detection in 45 SLE patients treated for 4 months were 55.6%,55.6%,88.9%,55.6%,55.6%,22.2%,22.2%,11.1% and 33.3% respectively.Conclusion The combination detection of autoantibody,immunoglobulin and complement is beneficial to diagnostic classification and prognostic evaluation of SLE patients.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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