Title: Protective Effects of dl-Tetrahydropalmatine on Focal Cerebral Ischemia-reperfusion Injury in Rats
Abstract: Objective To study the protective effects of dl-tetrahydropalmatine (THP) on focal cerebral ischemia-reperfusion injure in rats. Methods The modified LONGA method was used to make the model of focal cerebral ischemia-reperfusion injury in rats. THP was ip injected at 10.0,5.0,2.5 mg·kg-1 15 min before ischemia. The influence of THP were observed after ischemia for 3 h followed by reperfusion for 3 h on neurological deficits,size of cerebral infarction,lactate dehydrogenase (LDH) and creatine kinase (CK) activities in serum,contents of water,calcium,malondialdehyde (MDA) and superoxide dismutase (SOD) activity in brain tissue,and injure of brain ultrastructure in the model rats. Results THP dose-dependently reduced neurological deficit scores,decreased the size of cerebral infarction and inhibited LDH and CK in serum. THP 10.0 mg·kg-1 markedly lowered the water contents of injured brain,improved the damaged brain ultrastructure. THP also increased the activity of SOD,reduced the content of MDA and inhibited intracellular calcium accumulation in the cerebrum. Conclusion THP has protective effects against cerebral ischemia-reperfusion injury in rats,and mechanism of which might be related to inhibiting the lipid peroxides and reducing calcium accumulation.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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