Title: Protective effects of hippophe flavone on brain against ischemia-reperfusion injury in rats
Abstract: Objective: To study the protective effects of hippophe flavone (TFH) extracted from Hippophae Rhamnoid L. on brain against ischemia-reperfusion injury in rats. Methods: The rat model of cerebral ischemia-reperfusion injury was established by middle cerebral artery occlusion (MCAO) with nylon suture. The activities of creatine kinase (CK), lactate dehydrogenase ( LDH) and superoxide dismutase (SOD) and content of malonyldialdehyde (MDA) in serum were determined. The infarct sizes and water contents of brain after administration of different doses of TFH were also observed. Results: In rat model of cerebral ischemia-reperfusion injury, 3,15,30 mg/kg of TFH markedly decreased neurological deficit score, cerebral edema and infarction area, significantly reduced activities of CK, LDH and content of MDA in serum, enhanced activity of SOD in serum. Conclusion: TFH has the protective effects on brain against ischemia-reperfusion injury in rats. The ability to counteract lipid peroxidation may be one of its protective mechanisms.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot