Title: Recent progress in targeting protein-protein interactions for small-molecule drugs discovery
Abstract: Protein-protein interactions play a crucial role in numerous vital cell functions.Targeting protein-protein interactions is one of the most important strategies of drug discovery,but discovering small-molecule drugs that disrupt protein-protein interactions is an enormous challenge.However many small molecules which can modulate the protein-protein interactions have been discovered in the recent years.This review will focus on small-molecule inhibitors of protein-protein interactions in virus entry,apoptosis pathway and neurodegenerative diseases.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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