Title: EFFECT OF SHENQIBAOSHEN GRANULE ON EXPRESSION OF TGF-β_1 IN RATS WITH ADRIAMYCIN-INDUCED NEPHROSIS
Abstract: Objective:To observe the effect of shenbqibaoshen granule on the expression of TGF-β 1 in rats with adriamycin-induced nephrosis,discuss the mechanism of delaying the development of chronic renal failure.Methods:Adriamycin-induced nephrosis method was adopted,rats were divided into five groups.Quantitative test for uinary protein in 24hours,Scr,BUN and Ccr were detemined,renal tubulo-mesenchymal pathological changes were observed,expression of TGF-β 1 in renal tissue was observed by immunohistochemical method. Results:The urinary protein in 24 hours,Scr and BUN were obviously decreased ( P 0 01),the pathological changes of renal tubulo-mesenchymal was improved and expression of TGF-β 1 was decreased significantly in groups with medicines.Conclusion:Reducing urinary protein,blood Ccr and BUN,improving renal function and renal tubulo-mesenchymal injury,decreasing the expression of TGF-β 1 in renal tissue may be one of the mehanism of shenqihbaoshen granule to delay renal failure.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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