Title: Expression of Rho/Rho kinase of cardiac myocyte of heart failure model of pressure overload rats and intervention of Felodipine
Abstract: Objective To study the expression of Rho/Rho kinase of cardiac myocyte of heart failure pressure overload rat models subsequent to coarctation of ascending aorta and the effects of Felodipine on heart failure. Methods A model of heart failure induced by coarctation of ascending aorta was used in this study. 20 female Wistar operation rats were divided randomly into three groups (n=10). Control group(Natrii chloridi,01 ml)Heart failure (Natrii chloridi, 01 ml), Felodipine (5 mg/Kg), Qd p.o.,20 weeks after coarctation of ascending aorta operation.Treatment time was 4 weeks. Hemodynamics,ratio of LV weight to body weight, expression of RhoA and Rho kinase mRNA were investigated in the two groups and sham operation group. Results RhoA,Rho kinase mRNA leve were higher in heart failure when compared with sham. Felodipine could change the expression of RhoA,Rho kinase mRNA level.Conclusion These result indicated that heart failure was probably related to activating of RhoA,Rho kinase. Felodipine may contribute to the observed beneficial effects on heart failure by the decrease of RhoA,Rho kinase mRNA expression which may be a novel mechanism in the treatment of heart failure.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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