Title: Significance of expression of mutant P53 and MDR in bladder transitional cell carcinoma
Abstract: Objective To explore the significance of expression of P-gp and mutant p53 in bladder transitional cell carcinoma.Methods The expression of P-gp and p53 gene in specimens of 83 cases of patients with bladder transitional cell carcinoma were studied by immunohistochemical method.Results The positive expression rate of P-gp gene and mutant p53 gene was 71% and 51% respectively in specimens of 83 cases.The level of P-gp has no significantly statistical difference with the tumor pathological grade,clinical stage and prognosis(P0.05).The expression of p53 was higher in high grade tumors.It had a significantly statistical difference(P0.05).The mutant p53 positive rates were higher in recurrent patients(P0.01).Conclusion To examine P-gp is beneficial to selection of bladder carcinoma chemotherapeutic medicines.The mutant p53 gene may be involved in tumor progression in urotholied neoplasis.Overexpression of P-gp and mutant p53 of the tumors suggests that the patients have a worse prognosis and poor reaction to the therapy.The mutant p53 gene could be taken as an independent prognostic factor for tumor progression in BTCC.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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