Title: Protective and treatment effects of ginkgo biloba extract on ethanol-induced injury of skeletal muscles in rat
Abstract: Objective To study the protective and treatment effects of ginkgo biloba extract(EGB) on ethanolinduced injury in skeletal muscles of rat.Methods Seventy Sprague-Dawley rats were divided randomly into four groups:control group(10),alcohol group(20),EGB treatment group(20),EGB prevention and treatment group(20).The rate of cell apoptosis was determined by flow cytometer,contents of malondialdehyde(MDA),activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and inducible nitric oxide synthase(iNOS)were measured by spectrophotometric method.Results The apoptosis rate,the levels of MDA and iNOS were increased,the activities of SOD and GSH-Px were decreased in alcohol group than in control group.However,the apoptosis rate,levels of MDA and iNOS were downregulated,the activities of SOD and GSH-Px were upregualted in EGB761 group than in alcohol group.EGB761 prevention and treatment showed better effect than EGB761 treatment.Conclusion EGB761 prevention and treatment effect on the alcohol induced muscle injury might be related to the regulation of skeletal muscle cell apoptosis,MDA and iNOS and SOD and GSH-Px.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 1
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