Title: Effects of Copper Pre-administration on Rat's Metabolism of Serum Copper and Zinc,Activity of SOD and the Content of GSH
Abstract: To reveal the effects and mechanism of stress on metabolism of trace element in vivo,80 SD rats of 28 days old were divided into 4 groups at random,mamely feeding water group,low coper group(LCu),moderate copper group(MCu),and high copper group(HCu),feeding the four groups with deionized water lower,mod,and higher dose of copper respectively by intragastric administration for 3 weeks.Every group was randomly divided into ambient temperature contrasting groups and cold stress groups. Then observe and analyze concentration of serum copper and serum zinc,activity of superoside dismutase(SOD),reduced glutathionc(GSH)and malondialdehyde(MDA)of every group.The results showed that higher copper administration had not marked effects on the growth of clear SD rats.Serum copper/zinc ratio was not significantly changed.However,appropriate copper administration overly elevated activity of SOD and level of GSH.Serum copper decreased and serum zinc increased after the rats were disposed with cold stress.At the same time,SOD was consumed and level of GSH was notably heightened.Thus these results indicated that cold stress can change rats' metabolism of copper and zinc,activity of SOD and level of GSH,and appropriate administration of copper may make positive physiological effects in stress state.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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