Title: Effect of hypercapnia on nitric oxide-dependent pathway in rabbit model of acute lung injury.
Abstract: Objective To investigate whether hypercapnia is protective in the rabbit model of acute lung injury(ALI),and to study the ef-fect of hypercapnia on nitric oxide(NO)-dependent pathway and the potential mechanism.Methods Twenty-two New Zealand white rab-bits were randomly assigned to control group(group C,n =6),normocapnia group(group N,n =8),and hypercapnia group(group H,n = 8).The rabbits in groups N and H were intravenously injected with oleic acid(0.1 ml/kg)to establish the ALI model.The levels of in-ducible nitric oxide synthase(iNOS),NO,and nitrotyrosine in the lung tissues were detected.The changes in physiological parameters were monitored.Lung wet/dry weight ratio and pulmonary permeability index were measured,and the pathological chages were assessed.Results The levels of iNOS,NO,and nitrotyrosine in the lung tissues,the lung wet/dry weight ratio,and the pulmonary permeability index were signifi-cantly lower in group H than in group N(all P 0.05).Compared with group N,the peak airway pressure was significantly lower and the dynamic lung compliance and PaO2 significantly higher in group H(P 0.05).Histopathological changes in group H were less severe.Conclusion Hypercapnia is protective in the rabbit model of ALI.The mechanism might be associated with the inhibition of NO-dependent pathway by hypercapnia.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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