Title: Relationship of plasma homocysteine and interleukin-18 with acute cerebral infarction.
Abstract: Objective: To investigate the relationship of plasma IL-18 and total homocysteine(tHcy) concentration with acute cerebral infarction.Methods: A total of 103 patients with acute cerebral infarction admitted from April 2006 to May 2008 were included,and 46 healthy individuals were served as controls.The IL-18 and tHcy levels were measured.Results: The plasma concentrations of IL-18 in patients and control subjects were(212.57±86.72) pg/ml and(121.45±75.65) pg/ml respectively(P0.05),and the plasma concentrations of tHcy were(8.84±3.15) μmol/L and(6.92±1.23) μmol/L respectively(P0.05).The plasma concentrations of tHcy in patients with high IL-18 group(≥187 pg/ml) and normal IL-18 group(187 pg/ml) were(10.1±3.5)μmol/L and(8.3±2.6)μmol/L(P0.01).There was a positive correlation between plasma concentrations of IL-18 and tHcy(r=0.42,P0.05).Conclusion: The plasma IL-18 and tHcy levels are increased in the patients with acute cerebral infarction.IL-18 may be an independent risk factor of hyper-homocysteine in the acute cerebral infarction.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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