Title: Expression and Significance of OPN,PTEN and C-met in Hepatocellular Cancinoma
Abstract: Objective:To investigate the protein expression of OPN,PTEN and C-met and the correlatian with clinicopathological features in hepatocellular cancinoma.Methods:The protein expression of OPN,PTEN and C-met in hepatocelluar cancer tissue in 46 cases was examinated by immunohistochemical method.Results:The positive rates of OPN,PTEN and C-met were 71.7%,37.0%,76.1% in hepatocellular carcinoma tissue respectively.The expression of OPN and C-met were positively correlated to TNM staging and tumor size(P0.01,P0.01).No correlations were found between the expression of PTEN and clinicopath ological features of the tumor.Conclusion:The expression of OPN、C-met in the tissue of HCC is increased significantly,the expression of PTEN is decreasea.They might be used as objective indicators to predict the clinical features in hepatocellular cancinoma.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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