Title: Relafionship Between the Expression of Matrix Metal Proteinase-2 and Lymph Nodes Metastasis and Prognosis in Non-Small Cell Lung Cancer
Abstract: ve: To inquire the relationship between the expressiorr of matrix metal proteinase-2 (MMP-2) and lymph nodes metastasis and prognosis in non-small cell lung cancer (NSCLC). Methods: The immunohistochemical method( S-P method) was used to detect the expression of MMP-2 in 86 pathological specimen of lung cancer. Results:Positive rate of MMP-2 without lymph nodes metastasis was 48.8% (24/45) , the other with lymph nodes metastasis was 87. 8% (36/41). Statistical analysis chemonstrated that the expression of MMP-2 had positive correlation with lymph nodes metastasis ( P 0. 01). Survival time in patients with lung cancer with high expression of MMP-2 was longer than that in patiets with low expression of MMP-2. Conclusion: The high expression of MMP-2 can mention high metastasis capacity and low survival time in NSCLC.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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