Title: Effects of Minocycline on Apoptosis of Retinal Nerve Cells of Rats with Diabetic Retinopathy
Abstract:Objective: To study the effect of the Minocycline(MNC) on expression of apoptosis in retinal nerve cells of rat with diabetic retinopathy(DR).Methods: A total of 30 male SD rats were randomly divided ...Objective: To study the effect of the Minocycline(MNC) on expression of apoptosis in retinal nerve cells of rat with diabetic retinopathy(DR).Methods: A total of 30 male SD rats were randomly divided into negative control group,model control group and MNC treated group.Diabetes model was established by intraperitoneal injection of 60 mg/kg streptozotocin(STZ).Terminal Deoxynucleotidyl Transferase Biotin-dUTP Nick End Labeling(TUNEL staining) was used to observe neuron apoptosis in retina.All the experimental data were expressed by Mean+standard deviation.Results: Compared with the negative control group,TUNEL positive cells in retina were increased significantly(P0.01) in model control group.However,TUNEL positive cells in retina in MNC treated group were significantly decreased(P0.01).Conclusion: MNC can obviously decrease the expression of apoptosis in retina with DR.It is one of path of inhibiting impairment on retinal nerve cells with DR.Read More
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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Cited By Count: 1
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