Title: Expressions of Survivin protein and p63 protein in skin squamous cell carcinoma and their clinical significance
Abstract: Objective To investigate the expressions of Survivin protein and p63 protein in skin squamous cell carcinoma and their clinical significance. Methods The expressions of Survivin protein and p63 protein were detected by immunohistochemistry in 60 specimens of skin squamous cell carcinoma. The relationship between the expressions of these two proteins and the differentiated degrees of the tumor was analyzed. Results (1)Positive rate of Survivin protein was 73.3%.The more differentiated poorly was,the more positive rate highly was. However,there was no correlation with expression intensities. (2) In highly differentiated tumors,the staining of p63 formed a ring surrounding carcinoma nests .In low differentiated tumors , p63-positive cells were increased and disorderly arranged. A significant correlation between expression of the p63 and differentiated degree of skin squamous cell carcinoma was observed . Conclusion The positive rate of Survivin protein is closely correlated with the differentiated degrees of skin squamous cell carcinoma.Strong expression of Survivin protein indicates poor prognosis and probably become an important target of therapy. Overexpression of p63 may be contributed to acquisition of enhanced capabitity of proliferation ,aggression and anaplasia in skin squamous cell carcinoma.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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