Title: Experimental Studies of FFHQKL on Anti-hepatic Fibrosis in Rats
Abstract: Objective:In order to evaluate the curative effect and explore the possible mechanism of FFHQKL on anti-hepatic fibrosis.Methods:The rats was given intraperitoneal injection of porcine serum twice a week to establish the model of experimental immuno-damaged hepatic fibrosis. By using HE staining and special staining, the dynamical changes of hepatic histology of rats were observed to determine the curative effect of FFHQKL. By using immunohistochemical method, the dynamic changes in expression of MMP-13, TIMP-1 were determined in liver tissues from the experimental rats.Results:Compared with the control group, in which rats with hepatic fibrosis were not treated with FFHQKL, the histological examination of rat livers in the treatment groups showed that the total scores of hepatic fibrosis in treatment groups with high and low dosage were significantly decreased 2,3 months after the treatment(P0.01). With the decreased degree of liver fibrosis, the expression of TIMP-1 was significantly decreased and the expression of MMP-13 was significantly increased 2,3 months after the treatment in the high and low dosage groups of FFHQKL(P0.05 or P0.01).Conclusion:[WTBZ] FFHQKL could increase the expression of MMP-13,down-regulate the expression of TIMP-1, accelerate the degradation of ECM and reverse liver fibrosis.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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