Title: [Protective effects of shenmai injection on DPPH free radical-induced injuries in isolated hearts in rabbits].
Abstract:To examine the protective effects of shenmai injection (SM) on DPPH free radical-induced myocardial injury in isolated hearts in rabbits.The isolated rabbit hearts were perfused in a Langendorff model...To examine the protective effects of shenmai injection (SM) on DPPH free radical-induced myocardial injury in isolated hearts in rabbits.The isolated rabbit hearts were perfused in a Langendorff model. The left ventricular pressure (LVP), the first derivative of LVP (+dp/dtmax), left ventricular end-diastolic pressure (LVEDP) and heart rate(HR) were recorded. Coronary flow (CF) and creatine Kinase (CK) of coronary issue were measured.Perfusion with DPPH (0.25 mumol/L) for 5 min caused a significant impairment of cardiac function, as shown by a decrease in LVP and +dp/dtmax and an increase in LVEDP as well as the increased release of CK. Pretreatment with shenmai injection (1:320) for 10 min significantly improved the cardiac function and decreased the release of CK.Shenmai injection protects against the myocardial injury induced by free radical (DPPH) in isolated rabbit hearts.Read More
Publication Year: 2003
Publication Date: 2003-06-01
Language: en
Type: article
Indexed In: ['pubmed']
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