Title: Expression of nitric oxide synthase in rat brain during hypoxia.
Abstract: Objective: To establish an animal model of acute and chronic cerebral hypoxia in the rats, evaluate the expression of inducible nitric oxide(iNOS)and neuronal nitric oxide synthase(nNOS) and explore the possible mechanism of hypoxic brain injury. Methods: After the hypoxic models were made, The severity of hypoxic damage was assessed in the cortex and hippocampus by light microscopy. Immunocytochemistry was performed to detect the expression of iNOS and nNOS. The data were analyzed statistically. Results: iNOS-IR neurons appeared at 4th hour and reached peak at 5th hour after 1. 5 hours of hypoxia. Changes of nNOS-IR were not seen until 3rd day after hypoxia. Both iNOS-IR and nNOS-IR increased after 4 weeks of hypoxia. Conclusions: The results indicated that hypoxia which caused brain injury could induce the expression of nitric oxide synthases. NO might play an import role in brain damage during hypoxia.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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