Title: Effects of acute hypoxia on expression of nNOS in hippocampal CA1 of rats
Abstract: AIM: To investigate the expression of nNO S in hippocampal CA1 of rats against acute hypoxia. METHODS: The rats were divided into 3 groups (1. staying at the ground level, 2. undergoing 7 500m hypoxia for 1h and 3. undergoing 7500m hypoxia for 2h). By means of ABC imm unohistochemical staining, we investigate the expression of nNOS in hippocampus( CA1).The histomorphological changes of rat brains were examined by transmission electronmicroscope. RESULTS: In the experimental groups undergo ing hypoxia for 1h and 2h, the numerical density on area(NA) and the integral value of optical density(IOD) of nNOS positive cells in hippocampal CA1 were h igher than those in the staying at ground level group. CONCLUSION: The expression of nNOS in hippocampal CA1 tends to decrease against acute hypoxia.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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