Title: Determination of Serum Levels of Soluble Tumor Necrosis Factor Receptors in Patients with Esophageal Cancer
Abstract:Background: At present, the serum tumor markers for clinical diagnosis of esophageal cancer with high sensitivity and specificity have not been available. Aims: To determine the changes of serum solub...Background: At present, the serum tumor markers for clinical diagnosis of esophageal cancer with high sensitivity and specificity have not been available. Aims: To determine the changes of serum soluble tumor necrosis factor receptors (sTNFR) levels in patients with esophageal cancer, in order to explore their clinical significance in the diagnosis and surveillance of esophageal cancer. Methods: The serum levels of sTNFR-Ⅰ and sTNFR-Ⅱ were measured by avidin-biotin complex enzyme-linked immunosorbent assay (ABC-ELISA) in 56 patients with esophageal cancer and 10 healthy adults, and compared with the serum level of carcinoembryonic antigen (CEA). Results: The serum levels of sTNFR-Ⅰ and CEA in esophageal cancer patients were significantly higher than those in the healthy controls (P0.001), and the serum level of sTNFR-Ⅱ was unusually lower (P0.001); No significant differences in positivity rate were observed between sTNFR-Ⅰ and CEA, both of which were markedly lower than that of sTNFR-Ⅱ(P0.001). The serum levels of both sTNFR-Ⅰ and sTNFR-Ⅱ increased after resection of esophageal cancer, but no obvious change was seen in the level of CEA. Conclusions: The simultaneous determination of serum levels of sTNFR-Ⅰ and sTNFR-Ⅱ is useful in the diagnosis of esophageal cancer and in the evaluation of patient's immune status.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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