Title: Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients
Abstract: OBJECTIVE To investigate the possible relationship between vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphism and warfarin dose requirements in Chinese patients. METHOD Genotyping for the C1173T polymorphism in the VKORC1 gene was performed using a restriction enzyme digestion of PCR-amplified DNA in 102 Chinese patients treated with warfarin. RESULTS TT genotype was found in 83 patients (81.4%), CT genotype in 16 patients (15.7%) and CC genotype in 3 patients (2.9%). To achieve similar target INR range (1.5 - 2.5), the warfarin dose requirement was significantly lower in patients with TT genotype than that in patients with CT/CC genotypes (P < 0.01). CONCLUSION C1173T polymorphism in the VKORC1 gene might be one important determinant for warfarin dose requirement in Chinese patients.
Publication Year: 2007
Publication Date: 2007-07-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 3
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