Title: Study on mutation of new disease-caused gene MEF2A in Chinese patients with coronary artery disease.
Abstract: Objective: To explore the mutation of MEF2A gene exon 1 and 8 in Chinese patients with coronary artery disease(CAD).Methods: Mutation analysis of exon 1 and 8 of MEF2A gene was performed by use of polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP) and DNA direct sequencing in patients with CAD.Results:Mobility shift of SSCP in exon 1 and exon 8 of MEF2A gene was detected in 6 cases and in 7 cases respectly.But no mutation was found in the patients by DNA sequence analysis.Conclusion:No mutation in exon 1 and exon 8 of MEF2A gene was found in the patients with CAD.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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