Title: Analysis of relationship between K-ras gene mutation and breast cancer postoperative recurrence
Abstract: Objective To investigate the relationship between K- ras gene mutation and the postoperative recurrence of breast cancer. Methods The 149 breast cancer tissue samples were extracted for the observation group,normal breast tissue samples of the same patients as control group. the K- ras gene mutation was analyzed by polymerase chain reaction single stranded conformation polymorphism( PCR- SSCP) and direct sequencing method. The correlation between K- ras mutation and the postoperative recurrence of breast cancer was investigated. Results Mutation rate of K- ras in breast cancer tissue( 45. 64%) was significantly higher than that in normal breast tissue( 2. 01%)( P 0. 05). Cumulative recurrence rate of K- ras mutation in patients with postoperative 3 year was 79. 41%( 45 /68),significantly higher than that of patients without mutations( 25. 92%,21 /81)( P 0. 05). Conclusion K- ras gene mutation is one of the reasons leading to a high postoperative recurrence in breast cancer patients. K- ras gene mutation can be used as a clinical prognostic indicator.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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