Title: C-erbB-2 Protein Expression in Prostate Cancer
Abstract:Objective: To investigate c-erbB-2 protein expression in prostate cancer and its significance.Methods: Using immunohistochemical methods in detection of the c-erbB-2 protein expression in prostate can...Objective: To investigate c-erbB-2 protein expression in prostate cancer and its significance.Methods: Using immunohistochemical methods in detection of the c-erbB-2 protein expression in prostate cancer tissue.Results: A total of 21 cases of the 52 patients with prostate cancer were c-erbB-2 positive(40.4%).Positive expression was in plasma membrane.c-erbB-2 positive expression in high,medium differentiated types significantly lower than those in low,undifferentiated types(p0.05~0.01);the three-year-survival rates of patients with prostate cancer with c-erbB-2 positive expression were lower than those of patients with c-erbB-2 negative expression;the c-erbB-2 protein expression was not related to patients' age or tumor size(p0.05).Conclusion: c-erbB-2 oncogene expression of prostate cancer might be negatively correlated to the differentiation degree,and might predict the prognosis of prostate cancer.Read More
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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