Title: Preventive Effects of Asiatic Acid on Rat Hepatic Fibrosis Induced by Carbon Tetrachloride
Abstract: Objective: To study the effect of Asiatic acid(AA) to break off rat hepatic fibrosis induced by carbon tetrachloride(CCl_4).Methods: SD rats were randomly divided into model group,treatment group,normal group and drug group.Rats in the model and treatment groups were injected intraperitoneally with CCl_4 to induce hepatic fibrosis.Rats in the normal and drug groups were treated with equal peanut oil.The treatment and drug groups were given 2 mg of AA by gastric infusion.The model and normal groups were given equal water.At the end of experiment,the pathologic changes of liver tissue were observed.The serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST) and bilirubin were also measured.Results: The grades of hepatic fibrosis in the treatment group were significantly lower than those in the model group(P0.05).The serum levels of ALT,AST and bilirubin in the treatment group were also significantly lower than those in the model group(P0.05).Conclusion: AA is able to break off the hepatic fibrosis in rats induced by CCl_4.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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