Title: Serum β-HCG and Serum CA_(125) in Predicting Threatened Abortion
Abstract: Objective To test the predicting value of serum beta-human chorionic gonadotropin(β-HCG) and serum cancer embryo antigen (CA 125)alterations in patients with threatened abortion in order to provide prophylactic treatment. Methods Thirty-nine pregnant women aged 23~35 years with threatened abortion during the 4~12 weeks pregnancy were selected and enrolled in evaluation. Radioimmunoassay method was used to measure serum β-HCG and CA 125 levels when vaginal bleeding was first reported. Results Threatened abortion mostly happened during the 4~8 weeks pregnancy . When threatened abortion happened before a 7 weeks pregnancy, serum β-HCG level was not apparently different between the normal and the threatened pregnancies (P0.5). After the 7th week, the difference became apparent (P0.05). Difference of CA 125 level was not apparently (P0.5). Conclusions Sequential determinations of maternal β-HCG measurements appear to be a highly sensitive prognostic marker in patients with viable pregnancy at risk for abortion, which can predict the occurrence of abortion. In order to improve the pregnancy outcome , sequential assessments of maternal serum β-HCG in early stage pregnancy, particularly those who have the history of habitual abortion, and provide prophylactic treatment if the result is below the normal. Prophylactic treatment can be initiated at the 4 weeks pregnancy to those with a history of habitual abortion. The relationship between CA 125 and threatened abortion needs further study.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot