Title: The Effect of Single Oral Propafenone in Converting Paroxysmal Atrial Fibrillation.
Abstract: Department of Cardiology,Tianjin Medical University Hospital,Tianjin 300052,ChinaTo investigate the effect of single oral loading propafenone(450 mg) in convertion of paroxysmal atria fibrillation (PAF),thirty two patients suffering from PAF for over 2 hours each time and without heart failure above NYHA class II,sick sinus sydrome,atrioventricular or blanch block were divided into two groups.Group A (propafenone group):Eighteen patients took propafenone 450mg.Group B (control group) 14 patients took placebo.Then the heart rate/rhythm was observed using Holter or cardiogram monitor within 2,4 and 12 hours,and record ECG after sinus rhthym.Result:There was no marked difference between the two groups in age,gender,etiology,course of disease,diameter of left atrium ( P 0.05).Percentage on convertion of PAF in group A was 11% (2/18) within 2 hours,44.4% (8/18) within 4 hours and 61.1% (11/18) within 12 hours.That in group B was separately 0 (0/14), 7.1% (1/14) and 21.4% (3/14).There were significantly difference within 4 and 12 hours between the two groups ( P 0.05) and without severe side effect.Conclusion :The results indicate that single oral propafenone is effective to convertion of PAF rapidly in the patients without severe heart failure and bradyarrhythmia.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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