Title: Effect of Amiodarone on reversion of atrial remodeling in patients with idiopathic atrial fibrillation
Abstract: AIM: To observe the effect of amiodarone on reversion of atrial remodeling in enlarged atria of patients with idiopathic atrial fibrillation. METHODS: 94 continuous inpatients with idiopathic atrial fibrillation who were hospitalized from June 1998 to July 2000 were randomized into amiodarone group (n=32), propafenone group (n=32) and control group(n=30). Electrocardiogram (ECG), ultrasonography of heart, liver function, renal function and thyroid function were measured at before treatment, and 1, 3, 6, 12 month after treatment period respectively. RESULTS: Amiodarone and propafenone converted all of atrial fibrillation to sinus rhythm immediately after treatment, with a longer treatment period in amiodarone group (about 1 week) than that of propafenone group. At 12 month after treatment period, there was a significant higher sinus rhythm ratio in amiodarone ( 81% vs 20%, P0.01) and propafenone group (56% vs 20%, P0.01) than control group. There were a smaller left atrial diameter, a higher peak value of blood flow via mitral valve at early left ventricular diastole period (E value), a higher peak value of blood flow via mitral valve at left atrial diastole period (A value) and a higher E/A ratio at 1, 3, 6 and 12 month after treatment period than before treatment respectively in amiodarone group, with a significant difference between any two of different time point (P0.01). CONCLUSION: There was a significant effect of amiodarone on reversion of atrial remodeling in enlarged atria of patients with idiopathic atrial fibrillation.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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