Title: Significance of VEGF expression in differentiated thyroid carcinoma
Abstract: Objective To investigate the relationship between the clinicopathological features and the expression of vascular endothelial growth factor (VEGF) in differentiated thyroid carcinoma (DTC).Methods The VEGF expression was detected by immunohistochemistry in 57 DTCs (43 cases of papillary and 14 cases of follicular),45 hyperplastic lesions (31 cases of goiters,12 cases of adenomas and 2 cases of Graves diseases) and 19 normal thyroid tissues that had been fixed in formalin and embedded in paraffin.Results The positive expression rate of VEGF was 86.9%,17.8% and 10.5% in DTC,hyperplastic lesions and normal tissues,respectively.The expression of VEGF was significantly higher in cancer tissue than in hyperplastic lesions and normal tissues (P0.05).The proportion of overexpression of VEGF was higher statistically in T_3/T_4 stage,poor prognostic,recurrent cases than in control groups (P0.05).There was a positive correlation between the staining score of VEGF and the prognosis score of DTC (r=0.320,P=0.015).Conclusion The overexpression of VEGF is an auxiliary diagnosis and prognosis marker for DTC.To detect VEGF by immunohistochemistry facilitates us to identify poor-prognostic cases from DTC patients.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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