Title: Therapeutic Effects of XiaoHuangFang on Cholestatic Liver Fibrosis in Rats
Abstract: Objective: To explore the intervention of XiaoHuangFang on liver function and histopathology of rats with bile duct ligation.Method: Thirty rats were randomized into sham operation group and bile duct ligation(BDL) group.Rats in BDL group were divided into XiaoHuangFang group and model group by the end of two weeks,XiaoHuangFang group began to receive intragastric administration from the third week,sham operation group and BDL group received lavage of same amounts of psychological saline for three weeks.All the rats were sacrificed by the end of fifth week to obtain the serum and liver tissue.Result: Compared with sham operation group,activities of ALT,AST and ALP of model group and contents of TBIL remarkably increased(P0.05 or 0.01),contents of Alb lowered notably(P0.01);compared with model group,XiaoHuangFang can lower the activity of ALP and the content of TBIL remarkably,inhibit the decrease of Alb contents(P0.05 or 0.01) and reduce the contents of Hyp in liver tissue(P0.05),meanwhile pathology of liver fibrosis in XiaoHuangFang group showed that it relieved.Conclusion: XiaoHuangFang can obviously inhibit the formation of cholestatic liver fibrosis.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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