Title: Research of C57BL/6 mouse model of systemic Candida albicans infection
Abstract: AbstrcatTo establish a stable C57BL/6 mouse model of systemic candidiasis, the mice were challenged intravenously via the lateral tail vein with 2 × 107 or 106 C.albicans yeast cells, respectively. And then the organs of mice were taken out to examine the C. albicans and pathology. The results showed that C. albicans could be isolated from the spleen of all the mice and the histologic section of kidney exhibited C. albicans blastospores and hyphae, and abundant inflammatory cells. Mice immunized with phage displayed peptide and heat killed C. albicans acquired a resistance to systemic C. albicans infection as confirmed by fewer C. albicans cells in the kidneys. These results suggest that the C57BL/6 mouse model of systemic candidosis has been established stably when a suitable does of C. albicans was intravenously given to mice. The model may be used for studying the prevention and cure of systemic C. albicans infection.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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