Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2111656780', 'doi': 'https://doi.org/10.1128/iai.67.12.6637-6642.1999', 'title': 'Germ Tubes and Proteinase Activity Contribute to Virulence of <i>Candida albicans</i> in Murine Peritonitis', 'display_name': 'Germ Tubes and Proteinase Activity Contribute to Virulence of <i>Candida albicans</i> in Murine Peritonitis', 'publication_year': 1999, 'publication_date': '1999-12-01', 'ids': {'openalex': 'https://openalex.org/W2111656780', 'doi': 'https://doi.org/10.1128/iai.67.12.6637-6642.1999', 'mag': '2111656780', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10569785', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/97077'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/iai.67.12.6637-6642.1999', 'pdf_url': 'https://iai.asm.org/content/iai/67/12/6637.full.pdf', 'source': {'id': 'https://openalex.org/S128227336', 'display_name': 'Infection and Immunity', 'issn_l': '0019-9567', 'issn': ['0019-9567', '1070-6313', '1098-5522'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://iai.asm.org/content/iai/67/12/6637.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013673260', 'display_name': 'Marianne Kretschmar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140742', 'display_name': 'Institute of Medical Microbiology and Hygiene', 'ror': 'https://ror.org/04xqmb911', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210140742']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Marianne Kretschmar', 'raw_affiliation_strings': ['Institute of Medical Microbiology and Hygiene1 and'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Microbiology and Hygiene1 and', 'institution_ids': ['https://openalex.org/I4210140742']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011368040', 'display_name': 'Bernhard Hube', 'orcid': 'https://orcid.org/0000-0002-6028-0425'}, 'institutions': [{'id': 'https://openalex.org/I159176309', 'display_name': 'Universität Hamburg', 'ror': 'https://ror.org/00g30e956', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I159176309']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Bernhard Hube', 'raw_affiliation_strings': ['Institute for General Botany, Applied Molecular Biology III, University of Hamburg, 22609 Hamburg,2 and'], 'affiliations': [{'raw_affiliation_string': 'Institute for General Botany, Applied Molecular Biology III, University of Hamburg, 22609 Hamburg,2 and', 'institution_ids': ['https://openalex.org/I159176309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026359523', 'display_name': 'Thomas Bertsch', 'orcid': 'https://orcid.org/0000-0002-2447-3334'}, 'institutions': [{'id': 'https://openalex.org/I177802217', 'display_name': 'University of Mannheim', 'ror': 'https://ror.org/031bsb921', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I177802217']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Thomas Bertsch', 'raw_affiliation_strings': ['Institute of Clinical Chemistry,3 Faculty of Clinical Medicine Mannheim, University of Heidelberg, 68167 Mannheim,'], 'affiliations': [{'raw_affiliation_string': 'Institute of Clinical Chemistry,3 Faculty of Clinical Medicine Mannheim, University of Heidelberg, 68167 Mannheim,', 'institution_ids': ['https://openalex.org/I177802217', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062637687', 'display_name': 'Dominique Sanglard', 'orcid': 'https://orcid.org/0000-0002-5244-4178'}, 'institutions': [{'id': 'https://openalex.org/I2802229882', 'display_name': 'University Hospital of Lausanne', 'ror': 'https://ror.org/05a353079', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802229882']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Dominique Sanglard', 'raw_affiliation_strings': ['Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland4'], 'affiliations': [{'raw_affiliation_string': 'Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland4', 'institution_ids': ['https://openalex.org/I2802229882']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007941239', 'display_name': 'Renate Merker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Renate Merker', 'raw_affiliation_strings': ['Department of Electrical Engineering IEE, University of Technology, 01062 Dresden,5 Germany, and'], 'affiliations': [{'raw_affiliation_string': 'Department of Electrical Engineering IEE, University of Technology, 01062 Dresden,5 Germany, and', 'institution_ids': ['https://openalex.org/I78650965']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027642417', 'display_name': 'M. Carl Schroder', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140742', 'display_name': 'Institute of Medical Microbiology and Hygiene', 'ror': 'https://ror.org/04xqmb911', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210140742']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Meike Schröder', 'raw_affiliation_strings': ['Institute of Medical Microbiology and Hygiene1 and'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Microbiology and Hygiene1 and', 'institution_ids': ['https://openalex.org/I4210140742']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014991111', 'display_name': 'Herbert Hof', 'orcid': 'https://orcid.org/0000-0002-6366-2517'}, 'institutions': [{'id': 'https://openalex.org/I4210140742', 'display_name': 'Institute of Medical Microbiology and Hygiene', 'ror': 'https://ror.org/04xqmb911', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210140742']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Herbert Hof', 'raw_affiliation_strings': ['Institute of Medical Microbiology and Hygiene1 and'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Microbiology and Hygiene1 and', 'institution_ids': ['https://openalex.org/I4210140742']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010758522', 'display_name': 'Thomas Nichterlein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140742', 'display_name': 'Institute of Medical Microbiology and Hygiene', 'ror': 'https://ror.org/04xqmb911', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210140742']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Thomas Nichterlein', 'raw_affiliation_strings': ['Institute of Medical Microbiology and Hygiene1 and'], 'affiliations': [{'raw_affiliation_string': 'Institute of Medical Microbiology and Hygiene1 and', 'institution_ids': ['https://openalex.org/I4210140742']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.62, 'has_fulltext': False, 'cited_by_count': 107, 'citation_normalized_percentile': {'value': 0.913674, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '67', 'issue': '12', 'first_page': '6637', 'last_page': '6642'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10150', 'display_name': 'Diagnosis and Management of Fungal Infections', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10150', 'display_name': 'Diagnosis and Management of Fungal Infections', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Role of Fibroblast Activation in Cancer Progression', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11074', 'display_name': 'Anthelmintic Resistance in Veterinary Parasites', 'score': 0.9694, 'subfield': {'id': 'https://openalex.org/subfields/3404', 'display_name': 'Small Animals'}, 'field': {'id': 'https://openalex.org/fields/34', 'display_name': 'Veterinary'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pepstatin', 'display_name': 'Pepstatin', 'score': 0.7612689}, {'id': 'https://openalex.org/keywords/candidiasis', 'display_name': 'Candidiasis', 'score': 0.458823}], 'concepts': [{'id': 'https://openalex.org/C60987743', 'wikidata': 'https://www.wikidata.org/wiki/Q1460232', 'display_name': 'Virulence', 'level': 3, 'score': 0.8861433}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.80378443}, {'id': 'https://openalex.org/C2776350231', 'wikidata': 'https://www.wikidata.org/wiki/Q7166509', 'display_name': 'Pepstatin', 'level': 4, 'score': 0.7612689}, {'id': 'https://openalex.org/C2780917455', 'wikidata': 'https://www.wikidata.org/wiki/Q310443', 'display_name': 'Candida albicans', 'level': 2, 'score': 0.69896436}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.6936629}, {'id': 'https://openalex.org/C2780199535', 'wikidata': 'https://www.wikidata.org/wiki/Q223102', 'display_name': 'Peritonitis', 'level': 2, 'score': 0.65837526}, {'id': 'https://openalex.org/C145081991', 'wikidata': 'https://www.wikidata.org/wiki/Q2576388', 'display_name': 'Corpus albicans', 'level': 3, 'score': 0.48476475}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.4459204}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.24615604}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.20789516}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18659943}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08110967}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016282', 'descriptor_name': 'Aspartic Acid Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002176', 'descriptor_name': 'Candida albicans', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': True}, {'descriptor_ui': 'D002176', 'descriptor_name': 'Candida albicans', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': True}, {'descriptor_ui': 'D002177', 'descriptor_name': 'Candidiasis', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D010538', 'descriptor_name': 'Peritonitis', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D000410', 'descriptor_name': 'Alanine Transaminase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000410', 'descriptor_name': 'Alanine Transaminase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016282', 'descriptor_name': 'Aspartic Acid Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016282', 'descriptor_name': 'Aspartic Acid Endopeptidases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002176', 'descriptor_name': 'Candida albicans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002176', 'descriptor_name': 'Candida albicans', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002177', 'descriptor_name': 'Candidiasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002177', 'descriptor_name': 'Candidiasis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010179', 'descriptor_name': 'Pancreas', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D010538', 'descriptor_name': 'Peritonitis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010538', 'descriptor_name': 'Peritonitis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014774', 'descriptor_name': 'Virulence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000516', 'descriptor_name': 'alpha-Amylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000516', 'descriptor_name': 'alpha-Amylases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/iai.67.12.6637-6642.1999', 'pdf_url': 'https://iai.asm.org/content/iai/67/12/6637.full.pdf', 'source': {'id': 'https://openalex.org/S128227336', 'display_name': 'Infection and Immunity', 'issn_l': '0019-9567', 'issn': ['0019-9567', '1070-6313', '1098-5522'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC97077', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10569785', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/iai.67.12.6637-6642.1999', 'pdf_url': 'https://iai.asm.org/content/iai/67/12/6637.full.pdf', 'source': {'id': 'https://openalex.org/S128227336', 'display_name': 'Infection and Immunity', 'issn_l': '0019-9567', 'issn': ['0019-9567', '1070-6313', '1098-5522'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.42, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W109135854', 'https://openalex.org/W116845276', 'https://openalex.org/W1778564703', 'https://openalex.org/W1919706581', 'https://openalex.org/W1978341756', 'https://openalex.org/W1980346490', 'https://openalex.org/W1996281296', 'https://openalex.org/W1998073675', 'https://openalex.org/W2007171106', 'https://openalex.org/W2008173955', 'https://openalex.org/W2012004848', 'https://openalex.org/W2013120955', 'https://openalex.org/W2021274184', 'https://openalex.org/W2047118032', 'https://openalex.org/W2065837503', 'https://openalex.org/W2067554401', 'https://openalex.org/W2069241820', 'https://openalex.org/W2072926078', 'https://openalex.org/W2073414803', 'https://openalex.org/W2075832435', 'https://openalex.org/W2076503304', 'https://openalex.org/W2076738378', 'https://openalex.org/W2078784636', 'https://openalex.org/W2084021973', 'https://openalex.org/W2089819283', 'https://openalex.org/W2095906727', 'https://openalex.org/W2106551743', 'https://openalex.org/W2119823668', 'https://openalex.org/W2119993819', 'https://openalex.org/W2125605543', 'https://openalex.org/W2130497216', 'https://openalex.org/W2149300340', 'https://openalex.org/W2164028234', 'https://openalex.org/W2188461807', 'https://openalex.org/W2415666666', 'https://openalex.org/W2416575750'], 'related_works': ['https://openalex.org/W4362508968', 'https://openalex.org/W4309514212', 'https://openalex.org/W3029732278', 'https://openalex.org/W2894531340', 'https://openalex.org/W2778267304', 'https://openalex.org/W2742010288', 'https://openalex.org/W2367173716', 'https://openalex.org/W2347270899', 'https://openalex.org/W2247003880', 'https://openalex.org/W2102861863'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Peritonitis': [1], 'with': [2, 87, 103, 116, 144], 'Candida': [3], 'albicans': [4, 28, 143], 'is': [5], 'an': [6], 'important': [7], 'complication': [8], 'of': [9, 26, 50, 56, 71, 79, 110, 124, 141, 146, 181], 'bowel': [10], 'perforation': [11], 'and': [12, 62, 74, 81, 96, 126, 199], 'continuous': [13], 'ambulatory': [14], 'peritoneal': [15], 'dialysis.': [16], 'To': [17], 'define': [18], 'potential': [19], 'virulence': [20, 40, 45, 135, 227], 'factors,': [21], 'we': [22, 167], 'investigated': [23], '50': [24], 'strains': [25, 140], 'C.': [27, 142], 'in': [29, 38, 41, 83, 93, 105, 114, 136, 183, 228], 'a': [30, 121, 171, 177], 'murine': [31], 'peritonitis': [32], 'model.': [33, 138, 230], 'There': [34], 'was': [35, 46, 112, 120], 'considerable': [36], 'variation': [37], 'their': [39], 'this': [42, 137, 229], 'model': [43], 'when': [44], 'measured': [47, 92], 'as': [48, 67, 164], 'release': [49], 'organ-specific': [51], 'enzymes': [52], 'into': [53, 89], 'the': [54, 72, 84, 90, 97, 108, 186, 192, 203, 207], 'plasma': [55, 85], 'infected': [57], 'mice.': [58], 'Alanine': [59], 'aminotransferase': [60], '(ALT)': [61], 'α-amylase': [63], '(AM)': [64], 'were': [65], 'used': [66], 'parameters': [68], 'for': [69], 'damage': [70], 'liver': [73], 'pancreas,': [75], 'respectively.': [76], 'The': [77], 'activities': [78], 'ALT': [80, 125, 182, 204], 'AM': [82, 127], 'correlated': [86], 'invasion': [88], 'organs': [91], 'histologic': [94], 'sections': [95], 'median': [98], 'germ': [99], 'tube': [100], 'length': [101], 'induced': [102, 176, 205], 'serum': [104], 'vitro.': [106], 'When': [107], 'activity': [109, 180], 'proteinases': [111, 132], 'inhibited': [113], 'vivo': [115], 'pepstatin': [117, 217], 'A,': [118], 'there': [119], 'significant': [122], 'reduction': [123], 'activities.': [128], 'This': [129], 'indicates': [130, 221], 'that': [131, 169, 222], 'contributed': [133], 'to': [134, 163, 185, 191, 226], 'Using': [139], 'disruption': [145], 'secreted': [147], 'aspartyl': [148], 'proteinase': [149], 'gene': [150], 'SAP1': [151], ',': [152, 154, 156, 195, 198], 'SAP2': [153], 'SAP3': [155], 'or': [157], 'SAP4': [158], 'through': [159], 'SAP6': [160], '(collectively': [161], 'referred': [162], 'SAP4-6': [165], '),': [166], 'showed': [168], 'only': [170], 'Δ': [172, 193, 196, 200, 208], 'sap4-6': [173, 209], 'triple': [174], 'mutant': [175, 210], 'significantly': [178], 'reduced': [179, 215], 'comparison': [184], 'reference': [187], 'strain.': [188], 'In': [189], 'contrast': [190], 'sap1': [194], 'sap2': [197], 'sap3': [201], 'mutants,': [202], 'by': [206, 216], 'could': [211], 'not': [212], 'be': [213], 'further': [214], 'A': [218], 'treatment,': [219], 'which': [220], 'Sap4-6': [223], 'may': [224], 'contribute': [225]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2111656780', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-08-31T23:07:41.638191', 'created_date': '2016-06-24'}